At least 50 people have been killed and 200 others were injured in a shooting at a concert in Las Vegas.

A Las Vegas resident, named as Stephen Paddock, is suspected of being the man who opened fire on the Route 91 Harvest Festival on the Las Vegas Strip.

The suspect was killed by police on 32nd floor of the Mandalay Bay Hotel and Casino, situated across from the concert.

Nevada police said they have located a "female person of interest" in connection with the shooting.

Marilou Danley, 62, had been sought by police after gunfire tore through the crowd at the outdoor event during a set by country music star Jason Aldean.

The dead gunman is also believed to have checked into the hotel as a guest.

Clark County Sheriff Joseph Lombardo said officers confronted Paddock in the hotel.