WASPS will go to a sold-out Welford Road to take on Leicester Tigers on Saturday missing up to a third of the team that beat Gloucester last weekend.
Joe Simpson, Andrea Masi, Kearnan Myall and Jake Cooper-Woolley are all likely to miss out through injury.
Director of rugby Dai Young said: “We’ve picked up a hell of a lot of injuries from Sunday and a six-day turnaround is going to be hard for some of them.
“I don’t think many of them are going to be anything longer than seven to ten days, but six days doesn’t give you enough time to turn it around.”
Masi tweaked a knee against Gloucester and Simpson hurt a shoulder, while Cooper-Woolley has a toe injury and Myall has been suffering with back spasms.