Gareth Ainsworth is likely to be without the services of Marcus Bean after the midfielder picked up an injury in Tuesday's draw against Plymouth.
The midfielder has been a key part of Wycombe's mini unbeaten run but Ainsworth has been dealt the news that the stalwart could face a spell on the sidelines.
Paul Hayes and Matt Bloomfield are also missing through injury this weekend, as well as longer-term absentees, Scott Kashket and Anthony Stewart.
Myles Weston turned in an impressive display on Tuesday and he came through the match unscathed, hoping to kick on now with his Wanderers career.
Hartlepool have been handed a crushing blow as their captain Billy Paynter will miss the rest of the season through injury.
Carl Magnay continues to make a comeback from serious injury for Dave Jones' side but tomorrow's game will come too soon.
WYCOMBE LAST FIVE GAMES: LDWDD
HARTLEPOOL LAST FIVE GAMES: LWWLW