The police have appealed for witnesses to a ‘serious’ crash after two men were hospitalised, one with life-threatening injuries.

Thames Valley Police appealed for witnesses to the terrifying crash on Wycombe Road A4010 earlier today (November 10).

The smash happened at about 7am, closing part of Wycombe Road near Saunderton for hours and leading to a major emergency response with air ambulance in attendance.

A white Vauxhall Vivaro van and a blue Ford Focus were involved. Both drivers, both men in their forties, were injured.

One man sustained life-threatening injuries and he remains in critical condition in hospital.

READ MORE: Ambulance treats two men after crash on Wycombe Road A4010

A second man sustained serious injuries and is in hospital in a stable condition.

Investigating officer PC Michael Austin from the Joint Operations Roads Policing Unit said: “I am appealing for any witnesses to this collision to please come forward.

“Anyone with dash-cam footage that might assist our investigation should also please get in touch.

“You can contact us by calling 101 or by making a report on our website, quoting reference number 43230505618.

“The A4010 was closed while the incident was dealt with, thanks to those affected for your patience and cooperation.”