Two serious crashes have closed the A41 Bicester Road in Aylesbury this evening.
Thames Valley Police have closed the road in both directions between Paradise Orchard and Jackson Road.
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The road is also closed in both directions at Waddesdon Hill and Blackgrove Road
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The force have said that the road will 'remain so for some time'.
Drivers have been advised to use alternative routes and to avoid the area.
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